Estrogen Receptor beta-1 MBS438376 from MyBioSource.com

Product Specs
ItemEstrogen Receptor beta-1
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS438376
Quantity0.1 mg
ApplicationsELISA (EIA), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
Conjugate/TagUnconjugated
ReactivityHuman, Monkey, Mouse, Rat, Pig, Horse, Sheep
TargetEstrogen Receptor beta-1
IsotypeIgG2a
Molecular Weight53-59kDa
CloneERb455
HostMouse
ImmunogenEstrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics
NCBI Full Gene Nameestrogen receptor 2 (ER beta)
NCBI Gene AliasesER-BETA, NR3A2, ESTRB, ESRB, Erb, ESR-BETA
ClonalityMonoclonal